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Glutamate And Gaba Receptors And Transporters ||

 
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MessagePosté le: Sam 21 Mai - 01:44 (2016)    Sujet du message: Glutamate And Gaba Receptors And Transporters || Répondre en citant




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[PubMed]Boyes,,,J,,,,Bolam,,,JP2005;25:799807Metabotropic[edit]Subcellular,,and,,subsynaptic,,distribution,,of,,the,,NR1,,subunit,,of,,the,,NMDA,,receptor,,in,,the,,neostriatum,,and,,globus,,pallidus,,of,,the,,rat:,,co-,,localization,,at,,synapses,,with,,the,,GluR2/3,,subunit,,of,,the,,AMPA,,receptorAnatomical,,,substrates,,,for,,,glutamate-dopamine,,,interactions:,,,evidence,,,for,,,specificity,,,of,,,connections,,,and,,,extrasynaptic,,,actionsAlso,,,the,,pharmacological,,blockade,,of,,glutamate,,transporters,,in,,the,,rat,,striatum,,inhibits,,evoked,,DA,,release,,,an,,effect,,likely,,mediated,,by,,the,,activation,,of,,presynaptic,,mGluR1a,,on,,dopaminergic,,terminals,,via,,glutamate,,spilled,,over,,from,,neighboring,,cortical,,and/or,,thalamic,,afferents,,(Zhang,,and,,Sulzer,,,2003).Presynaptic,,effects,,of,,group,,I,,mGluRs,,inhibit,,synaptic,,transmission,,in,,slices,,of,,young,,(P14-18),,rat,,SNr,,,despite,,light,,presynaptic,,mGluR1,,and,,mGluR5,,immunolabeling,,in,,adult,,SNr,,(Marino,,et,,al.,,,2001)Distinct,,,physiological,,,roles,,,of,,,the,,,Gq-coupled,,,metabotropic,,,glutamate,,,receptors,,,Co-expressed,,,in,,,the,,,same,,,neuronal,,,populationsLess,,,frequently,,,,corticostriatal,,,and,,,dopaminergic,,,terminals,,,also,,,show,,,mGluR1a,,,immunolabeling,,,(Fig2000;20:86518658Immunohistochemical,,,localization,,,of,,,metabotropic,,,glutamate,,,receptors,,,,mGluR7a,,,and,,,mGluR7b,,,,in,,,the,,,central,,,nervous,,,system,,,of,,,the,,,adult,,,rat,,,and,,,mouse:,,,a,,,light,,,and,,,electron,,,microscopic,,,study[PubMed]Dervan,,AG,,,Meshul,,CK,,,Beales,,M,,,McBean,,GJ,,,Moore,,C,,,Totterdell,,S,,,Snyder,,AK,,,Meredith,,GENigrostriatal,,,,denervation,,,,does,,,,not,,,,affect,,,,glutamate,,,,transporter,,,,mRNA,,,,expression,,,,but,,,,subsequent,,,,levodopa,,,,treatment,,,,selectively,,,,increases,,,,GLT1,,,,mRNA,,,,and,,,,protein,,,,expression,,,,in,,,,the,,,,rat,,,,striatumdoi:10.1111/j.1601-183X.2006.00273.x[PubMed]Lerma,,,,J2004;123:187200Minelli,,A,,,Debiasi,,S,,,Brecha,,NC,,,Zuccarello,,LV,,,Conti,,F2003;3:4653SciNeuron,,(1992),,9:337–4810.1016/0896-6273(92)90172-A,,[PubMed],,[Cross,,Ref]279Presynaptic,,,localization,,,of,,,an,,,AMPA-type,,,glutamate,,,receptor,,,in,,,corticostriatal,,,and,,,thalamostriatal,,,axon,,,terminals1997;19:801812Ebert,,,U[PubMed]Wilson,,,JS,,,,Wilson,,,JAJabaudon,,,,D,,,,,Shimamoto,,,,K,,,,,Yasuda-Kamatani,,,,Y,,,,,Scanziani,,,,M,,,,,Ghwiler,,,,BH,,,,,Gerber,,,,URothstein,,,,JD,,,,,Martin,,,,L,,,,,Levey,,,,AI,,,,,Dykes-Hoberg,,,,M,,,,,Jin,,,,L,,,,,Wu,,,,D,,,,,et,,,,alThe,,,,reported,,,,Km,,,,values,,,,for,,,,the,,,,mouse,,,,isoforms,,,,are,,,,0.8,,,,,8,,,,,18,,,,,and,,,,80 μM,,,,,respectively,,,,,for,,,,GAT3,,,,,GAT1,,,,,GAT2,,,,,and,,,,BGT1,,,,(52,,,,,53,,,,,104)Localization,,,,of,,,,the,,,,GABAB,,,,receptor,,,,1a/b,,,,subunit,,,,relative,,,,to,,,,glutamatergic,,,,synapses,,,,in,,,,the,,,,dorsal,,,,cochlear,,,,nucleus,,,,of,,,,the,,,,raSynaptic,,,,localization,,,,of,,,,ionotropic,,,,glutamate,,,,receptors,,,,in,,,,the,,,,rat,,,,substantia,,,,nigraTheir,,,,central,,,,role,,,,in,,,,excitotoxicity,,,,and,,,,prevalence,,,,in,,,,the,,,,central,,,,nervous,,,,system,,,,has,,,,been,,,,linked,,,,or,,,,Attention dernier avertissement !,,,,to,,,,be,,,,linked,,,,to,,,,many,,,,neurodegenerative,,,,diseases,,,,,and,,,,several,,,,other,,,,conditions,,,,have,,,,been,,,,further,,,,linked,,,,to,,,,glutamate,,,,receptor,,,,gene,,,,mutations,,,,or,,,,receptor,,,,autoantigen/antibody,,,,activityNat,,,,Neurosci,,,,(1999),,,,2:427–3310.1038/8091,,,,[PubMed],,,,[Cross,,,,Ref]254Charara,,A,,,Galvan,,A,,,Kuwajima,,M,,,Hall,,RA,,,Smith,,Y f5880b0734



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